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Kasin say simplin urine test et makaamta ed masakbay ya yugtan na Alzheimer's disease, ya mangilukas na dalan parad saray programa na mass screening? Say balon Frontiers in Aging Neuroscience ya impanaral et talagan mangipapanengneng ed saya. Sinubok na saray researcher so baleg a grupo na saray pasyente na Alzheimer ya nanduruma so grabe ra tan mabunigas iran indibidual ya normal so kanonotan da pian naamtaan so pandumaan na saray biomarker na ihi.
Nalmoan dan say formic acid ed ihi et sensitibon pakapatnagan na subjective cognitive decline tan nayarin mangipapatnag na masakbay iran yugtan na Alzheimer's disease. Saray walan paraan pian na-diagnose so Alzheimer's disease et mabmabli, ag-kombeniente, tan ag-ontutukoy ed routine screening. Kabaliksan na saya ya maslak ed saray pasyente et na-diagnose labat no atrasado la parad epektibon panagtambal. Balet, say ag-invasive, agmabli, tan kombenientin urinalysis parad formic acid et nayarin eksakton kekerewen na saray doktor parad masakbay ya screening.
"Say sakit ya Alzheimer et sakey a sakit ya ag-ontutundan manbayag, kabaliksan to ya nayarin ontubo tan mansiansia ed loob na dakel a taon antis ya ompatnag so deperensya ed pakatebek," inkuan na saray autor. "Say masakbay ya yugtan na sakit et nagagawa antis na yugtan na agnauman ya dementia, ya sakey a balitok a bintana parad interbensyon tan panagtambal. Kanian, nakaukolan so baleg a panagsuri parad masakbay a yugtan na Alzheimer's disease ed saray maedad la."
Kanian, no importante so masakbay ya interbensyon, akin et anggapoy routine ya programa na panag-screen parad masakbay ya yugtan na sakit ya Alzheimer? Say problema et walad saray paraan na panagsukimat ya uusaren natan na saray doktor. Kaiba ed saraya so positron emission tomography na utek, ya mabmabli tan mangipapaarap ed saray pasyente ed radiation. Wala met iray biomarker test ya makadetekta na Alzheimer's, balet kaukolan so invasive blood draws odino lumbar punctures pian naala so cerebrospinal fluid, ya nayarin itunda na saray pasyente.
Balet, say urine test et aliwan makapasakit tan kombeniente, kanian maabig iratan parad mass screening. Anggaman saray researcher et akabirbir la na saray biomarker ed ihi parad Alzheimer's disease, anggapo ed saratan so matukoy pian nanengneng so masakbay iran yugtan na sakit, kabaliksan to ya say golden window parad masakbay a panagtambal et mairap nin siansia.
Saray researcher ed benegan na balon impanaral et datin nanaral na sakey ya organikon compound ya tatawagen ya formaldehyde bilang urine biomarker parad Alzheimer's disease. Balet, wala ni so kaukolan ya iyaligwas ed masakbay a pakaamta ed sakit. Diad sayan sankabaloan ya impanaral, say insentro ra et say formate, sakey a formaldehyde metabolite, pian nanengneng no kasin mas epektibo itan bilang biomarker.
Walay dagup na 574 a totoon akibiang ed impanaral, tan saray akibiang et balanglan normal so kanonotan da tan mabunigas iran boluntaryo odino walaan na nanduruman grado na iyaaligwas na sakit, manlapud subjective cognitive decline anggad sigpot ya sakit. Inaral na saray researcher so ihi tan dala na saray mibibiang tan nanggawa ira na psychological assessment.
Nalmoan na impanaral ya say urinary formic acid et signipikantin atagey ed amin ya grupo na Alzheimer's disease tan mikonektaan ed cognitive decline no ikompara ed saray mabunigas a kontrol, kaiba lay grupon walaan na masakbay ya subjective cognitive decline. Ipapanengneng na saya ya say formic acid et nayarin manserbin sensitibon biomarker parad saray masakbay ya yugtan na sakit ya Alzheimer.
Makapainteres, nen inaral na saray researcher so lebel na formate ed ihi ya inlaok ed saray biomarker na dala na Alzheimer, aromog dan mas susto so pangibaga ra ed no antoy yugtan na sakit ya dadalanen na sakey a pasyente. Balet, kaukolan so kaaruman ya panagsukimat pian natalosan so siglaotan na sakit ya Alzheimer tan say formic acid.
"Say urine formic acid et walaan na ekselentin inkasensitibo parad masakbay a panag-screen parad Alzheimer's disease," inkuan na saray autor. “Say urine biomarker testing parad Alzheimer's disease et kombeniente tan epektibo ed gastos tan nepeg ya ilaktip ed saray routine ya health screening na saray maedad la.”
Wang, Y. et al. (2022) Sistematikon repaso na urinary formic acid bilang sakey a posiblin balon biomarker parad sakit ya Alzheimer. Saray ketegan ed neurobiology na itatatken. doi.org/10.3389/fnagi.2022.1046066.
Tags: itatatken, sakit ya Alzheimer, biomarkers, dala, utek, chronic, chronic diseases, compounds, dementia, diagnostics, doktor, formaldehyde, neurology, positron emission tomography, research, tomography, urinalysis
Diad Pittcon 2023 diad Philadelphia, Pennsylvania, ininterbyu mi si Propesor Joseph Wang, say analo na Ralph N. Adams Prize ed Analytical Chemistry nen sayan taon, nipaakar ed inka-versatility na teknolohiya na biosensor.
Diad sayan interbyu, pantongtongan tayo so respiratory biopsy tan no panon itan ya magmaliw ya mausar ya kagawaan pian naaralan iray biomarker parad masakbay a pakaamta na sakit a kaiba si Mariana Leal, Team Leader ed Owlstone Medical.
Bilang kabiangan na SLAS US 2023 review mi, pantongtongan mi so lab na arapen tan no antoy itsura to ed si Luigi Da Via, GSK Test Development Team Lead.
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