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Say malagkit ya paway a layer na fungi tan bakterya, ya tatawagen ya “extracellular matrix” odino ECM, et singa jelly tan onkikiwas bilang proteksion a layer tan shell. Balet unong ed sakey ya agano nin impanaral ya nipalapag ed journal ya iScience, ya ginawa na University of Massachusetts Amherst a kaiba so Worcester Polytechnic Institute, say ECM na pigaran mikroorganismo et manporma na gel no walay oxalic acid odino arum nin simplin asido. googletag.cmd.push(function() { googletag.display('div-gpt-ad-1449240174198-2′); });
Lapud say ECM et walay importantin betang to ed amin a bengatla manlapud resistensya na antibiotic anggad saray barado ya tubo tan kontaminasyon na saray medikal ya kagawaan, say pakatalos no panon ya uusaren na saray mikroorganismo so mapeket iran gel layers da et walaan na malaknab ya implikasyon ed inagew-agew a bilay tayo.
"Lawas ak ya interesado ed microbial ECMs," inkuan nen Barry Goodell, propesor na microbiology ed University of Massachusetts Amherst tan senior author na papel. "Mabetbet ya iisipen na totoo ya say ECM et sakey ya inert protective outer layer ya manproprotekta ed saray mikroorganismo. Balet nayarin onkiwas met itan bilang sakey a dalan ya mangiiter na pankanawnawa ed saray sustansya tan enzyme ya onloob tan ompaway ed saray selula na mikrobyo."
Say coating et walaan na pigaran kimey: say inka-sticky to et mankabaliksan ya saray indibidual ya mikroorganismo et nayarin mankakasakey pian manporma na kolonya odino “biofilms”, tan no magenap so mikroorganismo ya manggawa ed saya, nayarin manbara ed saray tubo odino mankontamina ed saray kagawaan ed medisina.
Balet say shell et nepeg ya onloob met. Dakel a mikroorganismo so mangibubuga na nanduruman enzymes tan arum niran metabolites panamegley na ECM ed materyal ya labay dan kanen odino impeksionan (singa say manbubulok a kiew odino tissue na vertebrate), insan, no asumpal la na saray enzyme so kimey da ed panagtunaw, ipaarap da ray sustansya panamegley na ECM. say compound et nasesepsep lamet ed laman. extracellular matrix.
Kabaliksan na saya ya say ECM et aliwan sakey labat ya inert ya proteksion; Diad tua, singa impanengneng nen Goodell tan saray katrabaho to, saray mikroorganismo et ompatnag a walaan na abilidad a mangontrol ed inka-sticky na ECM da tan sirin say inka-permeability da. Panon dan gagawaen itan? Say litrato: B. Goodell
Diad saray tahong, say ipapaway da et ompatnag ya oxalic acid, sakey a kaslakan ya organic acid ya naromog ed dakel a tanaman. Unong ed adiskobre nen Goodell tan saray katrabaho to, dakel a mikrobyo so ompatnag ya manguusar na oxalic acid ya ipapaway da pian onpeket ed paway a layer na carbohydrates, a manporma na malagkit tan singa gel ya ECM.
Balet nen inimano na grupo, adiskobre da ya say oxalic acid et aglabat akatulong ed pakawala na ECM, no ag ingen “naregula” to met itan: no mas dakel so oxalic acid ya inyarum na saray mikrobyo ed carbohydrate-acid mixture, mas lalon onkakasil so ECM. No mas malet so ECM, mas nababalang to ray angkakabaleg ya molekula ya onloob o ompaway ed mikrobyo, bangta saray angkekelag ya molekula et mansiansian bulos ya onloob ed mikrobyo manlapud kaliberliber tan ontan met ed kasunian.
Sayan adiskobre et onsusuppiat ed tradisyonal a pakatalos na siensia no panon ya onloob ed kaliberliber so nanduruman klase na compound ya ipapaway na fungi tan bacteria manlapud sarayan mikroorganismo. Insuheri nen Goodell tan saray katrabaho to ya diad arum a kaso et nayarin mas manmatalek iray mikroorganismo ed panag-secrete na angkekelag a tuloy iran molekula pian naataki so matrix odino tissue ya pandedependian na mikroorganismo pian manbilay odino naimpektaan.
Kabaliksan na saya a say panag-secrete na angkelag iran molekula et nayarin walaan met na baleg a betang ed pathogenesis no saray angkakabaleg ya enzyme et ag makadalan ed microbial extracellular matrix.
"Ompatnag a walay pegley a dalan," inkuan nen Goodell, "a saray mikroorganismo so makapankontrol ed lebel na asido pian makaadapta ed sakey a partikular a kaliberliber, a pansiansiaen da so pigaran angkakabaleg iran molekula, a singa saray enzyme, bangta aabuloyan iray angkekelag a molekula a mainomay a makadalan ed ECM. "
Say pangi-modulate na ECM panamegley na oxalic acid et nayarin paraan pian naprotektaan na saray mikroorganismo so sarili da manlapud saray antimicrobial tan antibiotics, lapud dakel ed sarayan tambal et tugyopen na angkakabaleg iran molekula. Sayan abilidad na panag-customize so nayarin manunan sengegan pian natalonaan so sakey ed saray manunan babeng ed antimicrobial therapy, lapud say pangimaniobra ed ECM pian magmaliw ya mas mainomay ya onloob so nayarin mamaaligwas ed inkaepektibo na saray antibiotics tan antimicrobials.
"No nakontrol tayo so biosynthesis tan panag-secrete na angkekelag ya asido a singa say oxalate ed pigaran mikrobyo, nakontrol tayo met no antoy onloob ed saray mikrobyo, ya makatulong pian mas natambal tayo so dakel a sakit ya nanlapud mikrobyo," inkuan nen Goodell.
Kaaruman ya impormasyon: Gabriel Perez-Gonzalez et al., Say pidedeneng na oxalates ed beta-glucan: implikasyon parad fungal extracellular matrix tan metabolite transport, iScience (2023). DOI: 10.1016/j.isci.2023.106851
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